Tuberculosis Induces Premature Cellular Aging, Says Study

A recent study has pinpointed that the cells of humans and animals who have recovered from tuberculosis had prematurely aged 12 to 14 years.

After successful treatment for tuberculosis, survivors have a higher risk of recurrent infection and death. A recent study has pinpointed that the cells of humans and animals who have recovered from tuberculosis had prematurely aged 12 to 14 years.

“It’s possible that this premature cellular aging is one reason why survivors of tuberculosis have a high risk of mortality,” said Dr. Andrew DiNardo, assistant professor of infectious diseases at Baylor College of Medicine and senior author of the paper.

Diet in Tuberculosis | Tuberculosis Diet
Patients with tuberculosis should eat a healthy diet so that they build up their immunity to fight against tuberculosis.

‘Tuberculosis (TB) is a potentially serious infectious disease caused by a type of bacterium called Mycobacterium tuberculosis. The bacteria usually affect the lungs, but also can invade other organs.’

To measure the aging of the cells, researchers looked at the epigenetic clock of the cells. Epigenetics looks at how the DNA inside every cell is coiled. As we age, how the DNA is coiled changes, and severe infection is changing it in such a way to increase premature aging.

In this study, the researchers studied multiple cohorts and multiple tissue types, and discovered that tuberculosis induced perturbations in epigenetic regulation, specifically in the regulation mediated by DNA methylation. These changes correlated with oxidative stress-induced senescence and was associated with premature cellular aging. These processes were conserved across both guinea pigs and humans.

DiNardo, who also is with Texas Children’s Hospital, says that this is an important area to look into after any severe infection, including sepsis or even SARS-CoV-2. The severity of the infection also could play a role in the aging of the cells.

Skin Tuberculosis - Causes, Symptoms, Diagnosis, Treatment & Prevention
Skin tuberculosis is a rare form of tuberculosis that occurs outside the lung. Infection is exogenous through contact or internally from another infectious site.

“A multi-omic epigenetic clock assay could become part of the standard of care for infectious diseases and further inform increased risk for comorbidities after chronic conditions or environmental exposure,” said Dr. Cristian Coarfa, associate professor of molecular and cellular biology at Baylor and co-corresponding author of the paper. Coarfa also is with the Dan L Duncan Comprehensive Cancer Center at Baylor.

A multi-omic approach would integrate epigenomics and other ‘omics,’ such as proteomics (proteins produced), metabolomics (metabolites present) and microbiomics (microorganisms) data.

Quiz on Tuberculosis
Tuberculosis is a major health care concern, especially in Africa and South East Asia. Brush up your information on tuberculosis by taking this quiz.

“Now that we know the mechanism, there are some ways that we can target it to slow down and decrease the premature epigenetic aging that is happening in these cells,” Coarfa said.

Their report appears in the journal Aging.

The Lungs
The lungs are our organs of respiration. It is within these, that exchange of gases takes place.

Source-Eurekalert