The antibody response to natural infection with adeno-associated virus (AAV) in chimpanzees has been characterized by a new study.
Proposed Link Between Liver Cancer And Adeno-Associated Virus Rejected
About 90% of humans have AAV2 in their blood. AAV2 present in the DNA of liver cells from patients with liver cancer either slowed or had no effect on tumor growth.
About 90% of humans have AAV2 in their blood. AAV2 present in the DNA of liver cells from patients with liver cancer either slowed or had no effect on tumor growth.
‘The antibody response to natural infection with adeno-associated virus (AAV) in chimpanzees has been characterized by a new study.’
Coauthors Roberto Calcedo and James M. Wilson, University of Pennsylvania Perelman School of Medicine, Philadelphia, monitored a group of chimpanzees - chosen because of their genetic similarity to humans - for 10 years and measured the levels of circulating antibodies in response to infection with naturally occurring AAV. The authors discuss the difference observed in the immune response to natural AAV infection compared to administration of AAV vectors used to deliver gene therapy in the article entitled "AAV Natural Infection Induces Broad Cross-Neutralizing Antibody Responses to Multiple AAV Serotypes in Chimpanzees".
Human Gene Therapy Clinical Development Editor James M. Wilson, Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, said, "The study of chimps provided us a window into the type of antibody response that occurs following a natural AAV infection."
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Through gene therapy, the corrected liver cells were transplanted into the diseased liver of pigs with HT1, resulting in enzyme production.
Through gene therapy, the corrected liver cells were transplanted into the diseased liver of pigs with HT1, resulting in enzyme production.
Targeted Gene Therapy for Treatment for Emphysema
Emphysema, a chronic lung disease is caused by Alpha-1-antitrypsin deficiency and a copy of the gene to cells in the lung corrects the condition.
Emphysema, a chronic lung disease is caused by Alpha-1-antitrypsin deficiency and a copy of the gene to cells in the lung corrects the condition.
The Future of Gene Therapy
In cortical neurons, hypoxia-inducible factor 1 (HIF-1) attenuates amyloid-beta protein neurotoxicity and decreases apoptosis induced by oxidative stress or hypoxia.
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