Researchers propose a mechanism for how sleep disruption intensifies pain, revealing that targeting the neurotransmitter may disrupt the pain-sleep loss cycle.
The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption
Go to source). Through experiments conducted in mice, the researchers found that the heightened pain sensitivity than can result from chronic sleep disruption (CSD)—or CSD-induced hyperalgesia—involved signaling from a part of a brain known as the thalamic reticular nucleus (TRN).
Sleep Deprivation can lead to a Host of Serious Health Problems
Whether you have trouble sleeping or trouble staying asleep, it’s important that you address the causes of sleep deprivation and cultivate good sleep habits.
Whether you have trouble sleeping or trouble staying asleep, it’s important that you address the causes of sleep deprivation and cultivate good sleep habits.
‘The concentration of N-arachidonoyl dopamine (NADA), categorized as an endocannabinoid neurotransmitter, diminished within the thalamic reticular nucleus (TRN) due to the effects of sleep deprivation. #pain #sleepdeprivation #neurotransmitter’
Activity of the cannabinoid receptor 1, which is involved in controlling pain perception, also decreased in the thalamic reticular nucleus after CSD. The research was spearheaded by researchers from Massachusetts General Hospital (MGH), a founding member of Mass General Brigham (MGB), and featured in the journal Nature Communications.
Applying NADA to the TRN Alleviated CSD-Induced Hyperalgesia in Mice
This beneficial effect of administered NADA could be countered by blocking the cannabinoid receptor 1, suggesting that both the receptor and NADA play a role in pain sensitivity due to sleep deprivation.“We provide a mechanism as to how sleep disruption leads to exaggerated pain, suggesting that harnessing the endocannabinoid system might break the vicious cycle between pain and sleep loss,” says co–senior author Shiqian Shen, MD, the clinical director of MGH’s Tele Pain Program.
Quiz on Neck Pain
Neck pain is a troublesome condition that could leave the patient feeling uncomfortable. Test your knowledge on neck pain by taking this ...
Neck pain is a troublesome condition that could leave the patient feeling uncomfortable. Test your knowledge on neck pain by taking this ...
- The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption - (https://www.nature.com/articles/s41467-023-42283-6)
Source-Eurekalert
Epworth Sleepiness Scale
Measure your daytime sleepiness using this simple interactive tool, based on Epworth Sleepiness disorder Scale. Excessive Daytime Sleepiness is a type of hypersomnia characterized by persistent sleepiness and lack of energy.
Measure your daytime sleepiness using this simple interactive tool, based on Epworth Sleepiness disorder Scale. Excessive Daytime Sleepiness is a type of hypersomnia characterized by persistent sleepiness and lack of energy.
Foods Inducing Sound Sleep
Insomnia has become a serious health problem and people tend to depend on quick yet risky solutions to get rid of it. But here is the list of nature's best sleep inducing foods right in our kitchen.
Insomnia has become a serious health problem and people tend to depend on quick yet risky solutions to get rid of it. But here is the list of nature's best sleep inducing foods right in our kitchen.
