Understanding The Predictors Of Prostate Cancer

A new study could change the way doctors treat certain prostate cancer patients.The three strongest predictors for the outcome for a prostate cancer patient are grade, PSA level and pathologic stage. The summation of these three predictors is what determines the Gleason grading system or a Gleason score (GS). The most common Gleason score among patients with prostate cancer is seven. In a new study, researchers look to understand the prognosis of patients with a score of seven.

Researchers studied 412 patients with tumors that measured a Gleason score of seven and were treated with radical prostatectomy. They looked at the patient outcomes based on their Gleason pattern (GP). Different Gleason patterns of the tumor also help determine the Gleason score.

In the study group, researchers say 307 patients had primary GP three tumors, 105 patients had primary GP four tumors, and 17 had GP five tumors. Researchers found those with GP five had significantly shorter times to disease recurrence. Researchers also say patients with GP four and GP five had a higher risk for disease recurrence.

Researchers thus conclude when looking at Gleason scores of seven, those patients with GP four tumors are at risk for a more aggressive cancer. They say looking at the primary GP is easily accessible and clinically relevant predictor of disease recurrence in patients with GS seven prostate cancer. They hope this will help doctors in the management of patients with GS seven prostate cancer.