Corticosteroids such as prednisolone may impair healthy pregnancy, which may lead to poorer long-term outcomes for the baby.
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Use of Steroids in Infertility Treatment may Cause Miscarriage or Birth Defects"
‘Steroid drugs act as immune suppressants, preventing the body's immune system from responding to pregnancy. These drugs lead to further complications by suppressing the natural immune response.’
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"Corticosteroids such as prednisolone may impair healthy pregnancy, which may lead to poorer long-term outcomes for the baby," she noted. 
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Many women receive corticosteroids in the belief that reducing immune cells called "natural killer" cells will facilitate a pregnancy. However, this belief is mistaken, as despite their alarming name these cells are actually required for healthy pregnancy.
There is a great deal of medical and consumer misunderstanding about the role of the immune system in fertility and healthy pregnancy, Robertson said.
"Steroid drugs such as prednisolone act as immune suppressants, preventing the body's immune system from responding to pregnancy. But by suppressing the natural immune response, these drugs may lead to further complications," Robertson explained.
"The immune system plays a critical role in reproduction and fertility. Natural killer cells and other immune cells help to build a robust placenta to support healthy fetal growth. But if we suppress or bypass the body's natural biology, there can be dire consequences that don't appear until later," she added.
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"We argue that unless overt immune pathology is evident, utilization of corticosteroids is not warranted and may be harmful," the study noted.
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Source-IANS