Using Antibiotics may be Linked With Delirium and Other Brain Problems

The US researchers have found that antibiotics may be linked to a serious disruption in brain function, called delirium, and other brain problems.

Antibiotics are powerful drugs that fight bacterial infection. The US researchers have found that antibiotics may be linked to a serious disruption in brain function, called delirium, and other brain problems.

Delirium, which causes mental confusion, may also be accompanied by hallucinations and agitation.

Antibiotics - Use and Abuse
Antibiotics are among the most used and abused medications. This article explains some general features about antibiotics.

‘Antibiotics may be linked to a serious disruption in brain function, called delirium, and other brain problems.’

"People who have delirium are more likely to have other complications, go into a nursing home instead of going home after being in the hospital and are more likely to die than people who do not develop delirium," said author Shamik Bhattacharyya from Brigham and Women's Hospital in Boston, US.

A total of 54 different antibiotics were involved, from 12 different classes of antibiotics ranging from commonly used antibiotics such as sulfonamides and ciprofloxacin to intravenous antibiotics such as cefepime and penicillin.

"About 47% of patients had delusions or hallucinations, 14% had seizures, 15% had involuntary muscle twitching and 5% had loss of control of body movements. Moreover, EEG, a test that detects electrical activity in the brain, was shown abnormal in 70% of the cases. As much as 25% of the people who developed delirium had kidney failure," the researchers explained.

Natural Antibiotics to Fight Bacterial Infections
Fighting infections the natural way and preventing them is always more effective than consuming medicines and antibiotics to treat them.

The study, published online in Neurology, identified three types of delirium and other brain problems related to antibiotics.

While type 1 was characterized by seizures and most often associated with penicillin and cephalosporins, type 2 was marked by symptoms of psychosis and associated with procaine penicillin, sulfonamides, fluoroquinolones and macrolides.

Antibiotics may be Beneficial in Moderate Cholera
In contrast to the WHO recommendations, some researchers advocate the use of antibiotics in moderate as well as severe cases of cholera.

Both type 1 and type 2 had a quick onset of symptoms, within days. Once antibiotics were stopped, symptoms also stopped within days.

Type 3 was characterized by abnormal brain scans and impaired muscle coordination and other signs of brain dysfunction, and was only associated with the drug metronidazole.

Antibiotics Over Prescribed in Asthmatic Children
Antibiotics are often prescribed with antiasthma drugs when they may not be required.

The beginning of noticeable symptoms took weeks instead of days. Symptoms also took longer to go away once the antibiotic was stopped, the researchers elicited.

For the study, the researchers reviewed all available scientific reports and found case reports on 391 patients, over seven decades, who were given antibiotics and later developed delirium and other brain problems.

Source-IANS