The combined use of antidepressants and non-steroidal anti-inflammatory drugs (NSAIDs) was associated with a substantially increased bleeding risk.
![Using Antidepressants and Common Painkillers Together can Cause Bleeding in Patients Using Antidepressants and Common Painkillers Together can Cause Bleeding in Patients](https://images.medindia.net/health-images/1200_1000/depressive-medicine.jpg)
NSAID prescriptions were obtained and hospital records were used to identify time to first admission with intracranial hemorrhage within 30 days of a new prescription. Factors that could affect the results, such as age, sex, and use of other medications, were taken into account.
Compared with use of antidepressants alone, the team found that combined use of antidepressants and NSAIDs was associated with a substantially increased bleeding risk. They found no statistically meaningful differences in risk of bleeding between different types of antidepressant drugs, or with age.
Being male was the most common factor for a higher risk of bleeding with combined use of antidepressants and NSAIDs. The addition of NSAIDs to antidepressant treatment increased the risk of intracranial hemorrhage within 30 days of the combination starting, especially in men, the authors concluded.
The study is published in The BMJ.
Source-ANI