Caused by the Salmonella typhi, typhoid is a major cause of fever in children in low- and middle-income countries, responsible for around 11 million cases and more than 116,000 deaths a year worldwide.
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‘TCV vaccine effectively reduces the burden of typhoid and save lives in populations that lack clean water and improved sanitation in endemic areas.’
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Although TCV has been shown to protect against the disease in studies involving healthy volunteers in the UK, no efficacy studies in endemic populations had been completed.Read More..
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The study involved 20,000 children aged 9 months to <16 years of age, who were randomly given one of two vaccines; half received TCV and half received the Group A meningococcal (MenA) vaccine - the latter acted as the control group.
Blood tests showed that typhoid occurred in 7 participants who received TCV and 38 receiving Men A vaccine. The researchers noted that these were preliminary results, and that the study will continue to follow-up the participants for two years.
Andrew Pollard, Professor of Paediatric Infection and Immunity at Oxford University’s Department of Paediatrics, said: "This is the first study to show that a single dose of TCV is safe, immunogenic, and effective, which provides clear evidence that vaccination will help efforts to control this serious disease and is a strong endorsement of the WHO policy for vaccine implementation."
"The efficacy of these results in an endemic population adds to a growing body of evidence supporting the use of TCV to reduce disease and save lives in populations that lack clean water and improved sanitation," said Dr. Kathleen Neuzil, MD, MPH director of the Center for Vaccine Development and Global Health at the University of Maryland School of Medicine and director of TyVAC.
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Pakistan’s current typhoid outbreak is the first-ever reported outbreak of ceftriaxone-resistant typhoid and represents an alarming trend in the spread of drug-resistant typhoid. Not only is the strain resistant to ceftriaxone, the standard treatment in many parts of the world, but it is also resistant to the majority of antibiotics commonly used for typhoid, making it increasingly challenging and costly to treat.
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Source-Eurekalert