Why Is Novel Radiotracer an Effective Diagnostic Tool for Obese Patients?

In patients with higher body mass index, the new PET perfusion radiotracer, 18F-flurpiridaz can help diagnose coronary artery disease (CAD) with an increased sensitivity compared to 99mTc-SPECT myocardial perfusion imaging (MPI) (1^✔ ✔Trusted Source
Improved assessment of CAD in obese subjects with flurpiridaz F18 PET myocardial perfusion imaging: a subset analysis of the flurpiridaz F18 301 phase 3 study

Go to source). Obese individuals frequently have medical conditions such as diabetes, high cholesterol, and high blood pressure that put them at higher risk of developing CAD. Due to these risk factors, imaging obese patients for CAD is very important.

“Due to their body shape, it’s often hard to image obese individuals,” said Krishna Patel, MD, assistant professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai in New York. “This can result in inferior image quality and diagnostic performance despite requiring a higher dose of radiation.”

Unlocking the Potential of Novel Radiotracer

The study reports on a pre-specified subgroup of a phase III multicenter trial of 18F-flurpiridaz. A total of 604 patients with suspected CAD across 48 sites in the United States, Canada and Europe were enrolled in the study. Patients underwent one-day rest-stress 18F-flurpiridaz PET MPI or one- or two-day rest-stress 99mTc-SPECT MPI before undergoing invasive coronary angiography. MPI images were read by three experts blinded to clinical and invasive coronary angiography data. Sensitivity and specificity for 18F-flurpiridaz PET MPI and 99mTc-SPECT MPI were calculated and then compared between PET and SPECT MPI among obese and non-obese groups.

Of the 578 patients with evaluable studies, 298 (51.6 percent) were classified as obese. 18F-flurpiridaz PET MPI had a sensitivity of 77 percent and a specificity of 67 percent in diagnosing significant CAD, while 99mTc-SPECT MPI had a sensitivity of 69.2 percent and specificity of 61.9 percent. The sensitivity, specificity and accuracy of 18F-flurpiridaz PET MPI was similar in non-obese and obese sub-groups.

Patel also noted that 18F-flurpiridaz could significantly increase availability of and access to PET myocardial perfusion imaging across the country, and potentially all over the world. “We know that PET perfusion is the best noninvasive imaging modality for CAD; however, thus far, the availability of stress cardiac PET myocardial perfusion imaging is limited across the world, as both significant investment for the generator and large patient volume are required for it to make economic sense,” she said. “With availability as a unit dose, 18F-flurpiridaz can disrupt this space, as suddenly now most—if not all—centers that offer PET for oncology can now perform stress perfusion studies.”

Reference:

1. Improved assessment of CAD in obese subjects with flurpiridaz F18 PET myocardial perfusion imaging: a subset analysis of the flurpiridaz F18 301 phase 3 study - (https://www.researchgate.net/publication/299572030_Improved_assessment_of_CAD_in_obese_subjects_with_flurpiridaz_F18_PET_myocardial_perfusion_imaging_a_subset_analysis_of_the_flurpiridaz_F18_301_phase_3_study)

Source-Eurekalert