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Why Ketamine Can Relieve From Depression So Quickly

by VR Sreeraman on Jun 18 2011 9:15 PM

UT Southwestern Medical Center scientists are shedding new light on why the anesthetic drug ketamine can within a matter of hours ease symptoms of depression in people in patients

 Why Ketamine Can Relieve From Depression So Quickly
UT Southwestern Medical Center scientists are shedding new light on why the anesthetic drug ketamine can within a matter of hours ease symptoms of depression in people in patients with treatment-resistant depression.
"Ketamine produces a very sharp increase that immediately relieves depression," said Dr. Lisa Monteggia, associate professor of psychiatry at UT Southwestern and senior author of the study.

Typical antidepressant medications - one of the most widely prescribed classes of drugs in the U.S. each year - often take several weeks to relieve symptoms of depression. If they are not successful within 12 weeks, physicians must prescribe a different antidepressant to produce a response.

"Ketamine produces a fast-acting antidepressant effect, and we hope our investigation provides critical information to treat depression effectively sooner," Dr. Monteggia said.

"We now have a novel pathway to explore that may provide potential for the development of faster-acting and longer-lasting antidepressants," Dr. Monteggia said.

The study was recently published in the journal Nature.

Source-ANI


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