Z Sleeping Drugs in Dementia Not Safe

Higher doses of Z sleeping drugs are associated with an increased risk of falls, fractures, and strokes in dementia patients.

Higher risk of falls, fractures, and strokes are associated with usage of Z sleeping drugs among people with dementia, as per research from the University of East Anglia.

Dementia is characterized by a decline in memory and cognition, affecting behavior and activities of daily life. Sleeping issues are commonly seen in 90% of dementia patients, affecting their mental and physical health and also of their caregivers.

Can Worrying Too Much Cause Alzheimer's Disease?
Anxiety is associated with a higher risk of Alzheimer's disease progression.

‘Higher doses of Z sleeping drugs are associated with an increased risk of falls, fractures, and strokes in dementia patients. This highlights the need for developing non-pharmacological approaches among these patients to tackle sleep issues and social isolation during Covid-19.’

Z-drugs (e.g. Zopiclone, Zaleplon, and Zolpidem) are a class of sleeping pills – Nonbenzodiazepines known to treat insomnia. It is recommended for only short-term use (maximum of four weeks) in people with dementia.

Though the efficacy of these drugs is unclear, dementia patients are often prescribed high doses of Z-drugs This is associated with a greater adverse effect as seen with benzodiazepines or 'benzos' – a stronger class of sedative drugs, except for a lower mortality rate with Z-drugs.

Z-drugs among Dementia Patients:

Quiz on Sleep Disorder
The comfort of modern life comes at the cost of restful sleep! "Laugh and the world laughs with you, snore and you sleep alone-Anthony Burgess" Scientifically it is proven that a good night's sleep is imperative for maintaining a balance between the physical, emotional and behavioral well-being of a person.

To analyze the effects of these drugs and their dosage in dementia, the research team employed data from 27,090 dementia patients of average age 83 years in England, between January 2000 and March 2016. Among them 62% were women.

Adverse events of Z-drugs – fractures, falls, deep vein thrombosis, stroke, and death were monitored in 3,532 patients over two years. Data were compared to people with sleeping disturbances, who were not on any sedatives, and those who had been on prescribed benzodiazepines.

Tau Protein Unfolds Novel Biomarkers & Therapeutics for Alzheimer’s Disease
The pathological accumulation of tau proteins in Alzheimer’s disease (AD) unfolds its dynamic chemical transitions with the progression of the disease over time.

"For patients prescribed Z-drugs, 17 percent were given higher doses. And we found that these patients on higher doses were more at risk of falls and fractures, particularly hip fractures, and stroke - compared with patients who were not taking any medication for sleep disturbance", said Prof Chris Fox, from UEA's Norwich Medical School. "Patients already taking higher dose Z-drugs should not stop taking their medication, but we recommend that they should make an appointment to see their GP for a review", he added.

The study offers insights to avoid usage of long-term higher doses of sleeping pills in dementia patients. This urges the need to develop non-drug approaches for these patients to tackle sleep issues and social isolation during Covid-19.

Does Visual Illusion Explain Enigmatic Human Behavior?
Convolutional neural networks (CNN), an analog to the human visual cortex, are found to be deceived by visual illusions as do humans.

Source-Medindia