ADVERSE DRUG REACTIONS
DR T R RAMANUJAM M.D., C.MI.Biol (Lond)
INTRODUCTION
DEFINITION OF A.D.R AND DRUG INTERACTIONS
CLASSIFICATION OF ADVERSE DRUG REACTIONS
ADR DUE TO DRUG INTERACTIONS
CRITERIA FOR DRUG REACTIONS
CRITERIA FOR DRUG REACTIONS
a) Problems of the physician:
Did the physician test sensitivity to the drug?
Did the physician withdraw all unsuitable medications?
Did the physician known about the diet?
Did the physician was aware of the physico chemical and therpeutic characteristics of drugs?
Did the physician observe ADR himself?
Does the ADR pose immediate hazard or not?
b) Environmental problems:
Presence of environmental pollutant
Was the drug properly stored / date expired or not ?
c) Problem of the patient:
Did the patient receive the drug prescribed?
Did the patient take the drug prescribed?
Did the patient take the drug in proper dose?
Did the patient take any other OTC remedies or old prescription?
5. Surveillance methods of detecting A D R:
1. Anecdotal reporting by individual doctors.
2. Voluntary but organised reporting.
3. Post marketing surveillance.
