Clarithromycin - A Review
DR T R RAMANUJAM M.D., C.MI.Biol (Lond)
ANTIMICROBIAL ACTIVITY
CLINICAL PHARMACOKINETICS
CLINICAL EFFICACY
TOLERABILITY PROFILE
ADVERSE EFFECTS & DRUG INTERACTIONS
CHOOSING HOOSING MACROLIDES
CONCLUDING SUMMARY
BRIIGHTER SIDE OF CLARITHROMYCIN
DARKER SIDE OF CLARITHROMYCIN
CURRENT TRENDS IN MICROLIDE USE
DARKER SIDE OF CLARITHROMYCIN
Clarithromycin is potent inhibitor of CYP3A isoenzymes and therefore involves drug interactions with;
Theophylline, cyclosporin, tacrolimus, carbamazepine, digoxin, Rifamycins necesitasting therapeutic drug monitoring and dose adjustments.
Clarithromycin X Oral anticoagulants = serious bleeding diathesis
Clarithromycin X Zidovudine, Loratidine, Fluoxetin, Nitrazepam ergot derivatives all lead to increased plasma levels of interactants and toxic effects.
Clarithromycin X Terfinadine,astemizole,Cisapride = cardia arrhythmias leading to torsade de pointes etc.,
