Clarithromycin - A Review
DR T R RAMANUJAM M.D., C.MI.Biol (Lond)
ANTIMICROBIAL ACTIVITY
CLINICAL PHARMACOKINETICS
CLINICAL EFFICACY
TOLERABILITY PROFILE
ADVERSE EFFECTS & DRUG INTERACTIONS
CHOOSING HOOSING MACROLIDES
CONCLUDING SUMMARY
BRIIGHTER SIDE OF CLARITHROMYCIN
DARKER SIDE OF CLARITHROMYCIN
CURRENT TRENDS IN MICROLIDE USE
CURRENT TRENDS IN MACROLIDE USE
Recently Macrolides are emerging as important agents in the treatment of disorders like ;
Rheumatoid arthritis, Myocardial infarction (Acute coronary syndrome) both of which have infectious origin where infection act as a precipitating factor for inflammatory changes. Recently Azithromycin and Doxycycline combination are being tried by NIH for rheumatoid arthritis . The role of antibiotics in MI is based on the fact that patholgoical examination of coronary plaque have revealed infection associated with C.pneumoniae, H.pylori, Herpes viridae etc., and CMV associated transplant vasculopathy.
Recent pilot studies and controlled trials have demonstrated that macrolide anti microbial treatment against M.pneumoniae reduced the risk of recurrent coronary events.
Recently ROXI trials are underway in Acute Coronary Syndrome associated with QT syndrome.
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