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| Abbreviation | Expansion |
| S/S | Signs & Symptoms |
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| SA | Sinoatrial |
| SAA | Synthetic Amino Acid |
| SAB | Spontaneous Abortion |
| SABA | Supplied Air Breathing Apparatus |
| SAED | SemiAutomatic External Defibrillator |
| SAST | Serum Aspartate Aminotransferase |
| SB | Spina Bifida |
| SBE | Subacute Bacterial Endocarditis |
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| SBFT | Small bowel follow through |
| SBO | Small Bowel Obstruction |
| SBS | Short bowel syndrome |
| SC | Subcutaneous |
| SCBU | Special care baby Unit |
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| SCI | Spinal Cord Injury |
| SCr | Serum creatinine |
| SDFI | Secure Digital forensic Imaging |
| SEM | Systolic ejection murmur |
| SG | Swan-Ganz |
| SGA | Small for Gestational Age |
| SGGT | Serum gamma-glutamyl transpeptidase |
| SGOT | Serum Glutamic Oxaloacetic Transaminase |
| SGPT | Serum Glutamic-Pyruvic Transaminase |
| SHO | Senior House Officer |
| SIADH | Syndrome of inappropriate antidiuretic hormone |
| SIDS | Sudden Infant Death Syndrome |
| SIMV | Synchronous intermittent mandatory ventilation |
| SLE | Systemic Lupus Erythematosus |
| SLUD | Salivation, Lacrimation, Urination, Defecation |
| SMO | Standing Medical Orders |
| SNF | Skilled Nursing Facility |
| SOAP | Subjective, Objective, Assessment, Plan |
| SOB | Short(ness) Of Breath |
| SPECT | Single Photon Emission Computed Tomography |
| SPMS | Secondary preogressive multiple sclerosis |
| SPO2 | Saturation of peripheral Oxygen |
| SpR | Specialist Registrar |
| SQ | Subcutaneous |
| SR | Sedimentation Rate |
| SRIF | Somatotropin Release Inhibiting Factor |
| SS | Social Services |
| SSRI | Selective Serotonin Reuptake Inhibitor |
| SSS | Sick Sinus Syndrome |
| SSS | Subclavian Steal Syndrome |
| ST | Sinus Tachycardia (cardiac) |
| STD | Sexually Transmitted Disease |
| STH | Somatotropic Hormone |
| STM | Short Term Memory |
| SUI | Stress Urinary Incontinence |
| SVC | Superior Vena Cava |
| SVCAD | Single Vessel Coronary Artery Disease |
| SVD | Spontaneous Vaginal Delivery |
| SVR | Systemic Vascular Resistance |
| SVT | Supra-Ventricular Tachycardia |
| Sx | Surgery |
| Sx | Symptoms |
| Sz | Seizure |
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